Protein Protein Interactions in Drug Discovery PDF/EPUB

[Read] ➮ Protein Protein Interactions in Drug Discovery By Alexander Dömling – Anglo-saxon.co Treating protein protein interactions as a novel and highly promising class of drug targets this volume introduces the underlying strategies step by step from the biology of PPIs to biophysical and coTreating protein protein interactions as a novel and highly promising class of drug targets this volume introduces the underlying strategies step by step from the biology of PPIs to biophysical and computational methods for their investigation The main part of the book describes examples of protein targets for which small molecule modulators have been developed covering such diverse fields as cancer autoimmune disorders and infectious diseases Tailor made for the practicing medicinal chemist this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach From the contentsPrediction of intra and inter species protein protein interactions facilitating systems biology studiesModulators of protein protein interactions The importance of Three DimensionalityInteractive technologies for leveraging the known chemistry of anchor residuesSH3 Domains as Drug TargetsP53 MDM2 Antagonists Towards Non Genotoxic Anticancer TreatmentsInhibition of LFA 1ICAM interaction for treatment of autoimmune diseasesThe PIF binding pocket of AGC kinasesPeptidic inhibitors of protein protein interactions for cell adhesion receptorsThe REPLACE Strategy for generating Non ATP competitive Inhibitors of Cell Cycle Protein Kinases and.

Treating protein protein interactions as a novel and highly promising class of drug targets this volume introduces the underlying strategies step by step from the biology of PPIs to biophysical and computational methods for their investigation The main part of the book describes examples of protein targets for which small molecule modulators have been developed covering such diverse fields as cancer autoimmune disorders and infectious diseases Tailor made for the practicing medicinal chemist this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach From the contentsPrediction of intra and inter species protein protein interactions facilitating systems biology studiesModulators of protein protein interactions The importance of Three DimensionalityInteractive technologies for leveraging the known chemistry of anchor residuesSH3 Domains as Drug TargetsP53 MDM2 Antagonists Towards Non Genotoxic Anticancer TreatmentsInhibition of LFA 1ICAM interaction for treatment of autoimmune diseasesThe PIF binding pocket of AGC kinasesPeptidic inhibitors of protein protein interactions for cell adhesion receptorsThe REPLACE Strategy for generating Non ATP competitive Inhibitors of Cell Cycle Protein Kinases an.

protein pdf protein free interactions pdf drug download discovery kindle Protein Protein epub Interactions in pdf Protein Interactions in mobile Protein Protein Interactions in Drug Discovery MOBITreating protein protein interactions as a novel and highly promising class of drug targets this volume introduces the underlying strategies step by step from the biology of PPIs to biophysical and computational methods for their investigation The main part of the book describes examples of protein targets for which small molecule modulators have been developed covering such diverse fields as cancer autoimmune disorders and infectious diseases Tailor made for the practicing medicinal chemist this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach From the contentsPrediction of intra and inter species protein protein interactions facilitating systems biology studiesModulators of protein protein interactions The importance of Three DimensionalityInteractive technologies for leveraging the known chemistry of anchor residuesSH3 Domains as Drug TargetsP53 MDM2 Antagonists Towards Non Genotoxic Anticancer TreatmentsInhibition of LFA 1ICAM interaction for treatment of autoimmune diseasesThe PIF binding pocket of AGC kinasesPeptidic inhibitors of protein protein interactions for cell adhesion receptorsThe REPLACE Strategy for generating Non ATP competitive Inhibitors of Cell Cycle Protein Kinases an.

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